A Cell Biologist's Guide to Modeling and Bioinformatics by Raquell M. Holmes

By Raquell M. Holmes

A step by step advisor to utilizing computational instruments to resolve difficulties in phone biology

Combining professional dialogue with examples that may be reproduced via the reader, A mobilephone Biologist's consultant to Modeling and Bioinformatics introduces an array of informatics instruments which are on hand for examining organic facts and modeling mobile procedures. You learn how to totally leverage public databases and create your personal computational versions. All that you just want is a operating wisdom of algebra and mobile biology; the writer offers all of the different instruments you want to comprehend the required statistical and mathematical methods.

Coverage is split into major categories:

  • Molecular series database chapters are devoted to gaining an realizing of instruments and strategies—including queries, alignment tools, and statistical value measures—needed to enhance searches for series similarity, protein households, and putative useful domain names. Discussions of series alignments and organic database looking out specialize in publicly to be had assets used for historical past examine and the characterization of novel gene products.
  • Modeling chapters take you thru all of the steps desirous about making a computational version for such simple study components as mobile cycle, calcium dynamics, and glycolysis. every one bankruptcy introduces a brand new simulation tooland relies on released examine. the combo creates a wealthy context for ongoing ability and information improvement in modeling organic examine systems.

Students mobile biologists can enhance the elemental talents had to study computational mobile biology. This precise textual content, with its step by step guideline, permits you to attempt and improve your new bioinformatics and modeling abilities. References are supplied that will help you reap the benefits of extra complex concepts, applied sciences, and training. 

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Additional resources for A Cell Biologist's Guide to Modeling and Bioinformatics

Sample text

Instant Notes Series. New York: BIOS Scientific Publishers Limited; 304p. Wilbur WJ, Lipman DJ (1983). Rapid similarity searches of nucleic acid and protein data banks. Proceedings of the National Academy of Sciences USA 80:726–730. Wootton JC, Federhen S (1996). Analysis of compositionally biased regions in sequence databases. Methods in Enzymology 266:554– 71. Zhang Z, Schwartz S, Wagner L, et al. (2000). A greedy algorithm for aligning DNA sequences. Journal of Computational Biology 7(1-2):203–214.

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Ma B, Tromp J, Li M (2002). PatternHunter: faster and more sensitive homology search. Bioinformatics 18(3):440–445. Marth GT, Korf I, Yandell MD, et al. (1999). A general approach to single-nucleotide polymorphism discovery. Nature Genetics 23(4):452–456. Mount D (2001). Bioinformatics: Sequence and Genome Analysis. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 564p. Needleman SB, Wunsch CD (1970). A general method applicable to the search for similarities in the amino acid sequence of two proteins.

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