Adult Stem Cells, 1st Edition by Kursad Turksen (Author)

By Kursad Turksen (Author)

This accomplished overview of our present knowing of grownup stem mobile varieties and their rules examines the derivation, characterization, and software of grownup stem cells present in skeletal muscle, dental pulp, prostate, kidney, the attention, internal ear, and different tissues. The authors pay designated realization to grownup stem telephone plasticity and their application in general tissue homeostasis, in addition to their functions in regenerative drugs.

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DIFFERENTIATION CAPACITY OF SPERMATOGONIAL STEM CELLS AND THEIR PRECURSORS Spermatogonial stem cells originate from primordial germ cells (PGCs), which derive from epiblast cells (embryonal ectoderm) (59). During fetal development, the PGCs proliferate and migrate to the genital ridges, where they become enclosed in the seminiferous cords formed by Sertoli cell precursors. Once in the seminiferous cords, the cells are called gonocytes, which 30 de Rooij Fig. 6. Proposed scheme of spermatogonial multiplication and stem cell renewal in primates.

In the human, this means that they divide only once every 16 d (53,54). Adark spermatogonia in the normal situation are quiescent cells and are supposed to be reserve (stem) cells. 2. Nature of the Apale and Adark Spermatogonia An important question is whether Apale and Adark are spermatogonial stem cells. To answer this question, an obvious approach is to look at the topographical arrangement of these spermatogonia on the basal membrane. In the normal seminiferous epithelium, the density of Apale and Adark spermatogonia is relatively high.

The activation first causes the Adark to acquire the Apale appearance and accompanying proliferative activity. Then, having become Apale, they try to divide, but because of the lethal radiation damage acquired during the time they were Adark, proper division fails, and the cells enter apoptosis. 4. Conclusion The A pale and A dark spermatogonia in primates are topographically arranged in singles, pairs, and chains of spermatogonia. Unless spermatogonial renewal and multiplication in primates is totally different from that in nonprimate mammals, only the singles among them are stem cells and are comparable to the As in nonprimates (Fig.

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