By Gerardo R. Vasta PhD, Hafiz Ahmed PhD
Introduces Groundbreaking techniques for Assessing Lectin Function
Lectins and their ligands are below relatively a heavy microscope as a result of their capability functions to pharmacology, immunology, melanoma remedy, and agriculture. With growing to be curiosity within the glycobiology box, the physique of study relating to lectin roles has grown at an explosive price, quite long ago two decades. Animal Lectins: A useful View presents the main updated research of those carbohydrate-binding, and almost certainly lifesaving, proteins in a single finished quantity.
This standard-setting source offers new insights into the organic roles of such a lot animal lectins, together with their functionality in an infection prevention via innate immunity. It additionally discusses such lectin behaviors as:
- Glycoprotein folding
- Sorting and targeting
- Cell adhesion
- Cell-cell interactions and signaling
Describes the Structural foundation of Protein-Carbohydrate Interactions
Under the editorial information of 2 major protein chemistry specialists and with contributions from well-recognized box gurus, this e-book logically and systematically discusses either intracellular and extracellular lectin features. it truly is a necessary springboard for destiny box study and a transparent and concise wisdom base that glycobiology, biochemistry, and immunology researchers can't have the funds for to be without.
Read Online or Download Animal Lectins: A Functional View PDF
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Extra resources for Animal Lectins: A Functional View
1992 Lectins as blood typing reagents. In: Franz, H. ), Advances in Lectin Research, Vol. 5. Ullstein Mosby, Berlin, pp. 51–94. 8. Noguchi, H. 1903 On the multiplicity of the serum haemagglutinins of cold-blooded animals. Zentralbl. Bakteriol. Abt. l Orig. 34, 286. 9. Cantacuzene, J. 1912 Sur certains anticorps naturels observes chez Eupagurus prideauxii. R. Soc. Biol. 73, 663. 10. M. J. 1952 Neutralization of the anti-H agglutinin in eel serum by simple sugars. Nature 169, 825–826. 11. J. M. 1968 Isolation and characterization of a hemagglutinin from Limulus polyphemus.
Nature 169, 825–826. 11. J. M. 1968 Isolation and characterization of a hemagglutinin from Limulus polyphemus. J. Mol. Biol. 32, 453–465. 12. Hammarstrom, S. A. 1969 Purification and characterization of a blood-group A reactive hemagglutinin from the snail Helix pomatia and a study of its combining site. Biochemistry 8, 2696–2705. indd 8 9/1/2008 5:59:35 PM Introduction to Animal Lectins 9 13. F. R. 1971 Monosaccharides as specific precipitinogens of eel anti-human blood group H (O) antibody. Biochemistry 10, 3749–3760.
Describe the structural features of chitinases and chilectins, which may have arisen from the gene duplication events. Chilectins have lost the ability to cleave chitin due to mutations in the active site, but retain the ability to bind carbohydrates. REFERENCES 1. H. 1988 Bifunctional properties of lectins: Lectins redefined. Trends Biochem. Sci. 13, 480–482. 2. L. 1899 Recherches experimentales sur une agglutinine produite par la glande de l’albumen chez l’Helix pomatia. R. Acad. Sci. 129, 233.