By Douglas R. Green, John C. Reed
Apoptosis, or mobile loss of life, will be pathological, an indication of disorder and harm, or physiological, a strategy crucial for regular wellbeing and fitness. This pathological dysregulation of mobilephone dying could be characterised via both an excessive amount of lack of crucial cells within the middle, mind, and different tissues with little regenerative ability or by way of too little cellphone turnover in self-renewing tissues, giving upward push to melanoma and different maladies. it is a technique of basic value for improvement and general wellbeing and fitness, that is altered in lots of ailment stipulations. This ebook, with contributions from specialists within the box, offers a well timed compilation of stories of mechanisms of apoptosis. The ebook is geared up into 3 handy sections. the 1st part explores different techniques of mobile dying and the way they relate to each other. the second one part makes a speciality of organ-specific apoptosis-related ailments. The 3rd part explores cellphone dying in non-mammalian organisms, resembling vegetation. This complete textual content is a must-read for all researchers and students drawn to apoptosis.
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Extra resources for Apoptosis: Physiology and Pathology
Humans with X-linked lymphoproliferative disorder (XLP) have been identified with XIAP gene mutations that lead to defective expression of this IAP family member. Lymphocytes from patients with XLP have no detectable XIAP expression and demonstrate enhanced apoptosis in response to various apoptotic stimuli. The lymphoproliferative (rather than immunodeficient) phenotype seen in XIAP-deficient XLP patients appears, in part, to result from the observed low numbers of natural killer T-lymphocyte (NKT) cells, suggesting that XIAP may have a role in promoting NKT cell development or survival in humans.
Mol Cell 26:689–702. Morgan J, Yin Y, Borowsky A (1999) Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res 59: 6205–13. O’Connor DS, Grossman D, Plescia J, Li F, Zhang H, Villa A, Tognin S, Marchisio PC, Altieri DC. (2000) Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin. Chai J, Shiozaki E, Srinivasula SM, Wu Q, Dataa P, Alnemri ES, Proc Natl Acad Sci U S A 97:13103–17.
DR6 (TRAMP) Figure 3-1. The human death domain-containing receptors and their known ligands. The six human death domain (DD)–containing receptors are transmembrane proteins that contain repeats of two to four cysteinerich domains (CRDs) in the extracellular portion required for the ligation of their cognate ligand and an intracellular DD capable of recruiting adaptor proteins that will trigger downstream intracellular signals (light gray for CD95/TRAIL systems and dark gray for TNF-R/DR3 systems).